Biological Evaluation of 1, 2-bis (2, 4, 6-Trinitrophenyl) Hydrazine

Many hydrazine derivatives show remarkable biological activities [1]. Hydrazine derivatives are well known among pesticides, drugs, amino acid precursors, and synthetic building blocks for heterocycle synthesis. Several similar compounds were shown to be effective for treatment of tuberculosis, Parkinson’s disease, and hypertension [2]. Also, hydrazine-based peptidomimetics (azapeptides) are found to be potent agents against diseases effects such as hepatitis, AIDS, and SARS [3]. Therefore, it can be easily seen that synthesis of substituted hydrazines is a matter of great interest. Hydrazine derivatives are widely used compounds in the pharmaceutical, agrochemical, polymer and dye industries and also as precursors in organic synthesis [4]. In addition, some hydrazines display neuroprotective properties and are used as antidepressant drugs [5]. Hydrazine-based peptidomimetics (azapeptides) were found to be potent agents against hepatitis [6], AIDS [7] and SARS [8]. Hydrazine derivatives are also being used for the derivatization of nanostructures [9]. Therefore, the synthesis of hydrazine derivatives is a matter of significant interest from both theoretical and practical perspectives [10]. Unsubstituted or substituted halo nitro and nitroso compounds and their metabolites are reported 11 as potent, selective and non-toxic inhibitors and supressants of cancer growth and viral infections in a mammalian host. The nitro compounds are particularly useful for treatment and suppression of tumors and viruses associated with breast cancer, AIDS, herpetic episodes and viral infections. In present work we report the synthesis (Scheme-1) and characterization of 1, 2-bis (2, 4, 6-trinitrophenyl) hydrazine, and its evaluation for antimicrobial applications. CODEN (USA): IJPB07 ISSN: 2320-9267